The (lonely, discouraging) Journey to Nanite
While acknowledging that not everybody finds deeply technical discussions of things they only faintly understand to be compelling viewing, I found Brian Karis's 90-minute keynote address totally engrossing. He discusses his year-long intellectual journey towards what became Unreal Engine 5's virtualized geometry technology not in terms of the technical triumph that it ultimately was but rather the messy process of dead-ends, hunches, and lonely groping in the dark that it took to get there.
In his relating of the experience of working on a problem where a solution was far from guaranteed, Karis's humility and curiosity are genuinely inspirational.